Objective: To explore the effects of percutaneous endo-aortic repair on patients with aortic dissection. Methods: Select 100 patients with aortic dissection who were treated in our hospital from June 2020 to June 2021 as the research objects. The patients were divided into two groups, and different treatment methods were used. The percutaneous aorta was analyzed and compared. The clinical effect of endovascular repair. Results: There were significant differences in hospitalization time, operation time and incidence of adverse reactions between the two groups of patients, expressed as P<0.05. The incidence of adverse reactions in the experimental group was lower, the operation time and hospital stay were shorter, and the effect was better. Conclusion: The application of percutaneous aortic endovascular repair to the treatment of patients with aortic dissection has a significant clinical effect, which can shorten the patient’s hospital stay, reduce the incidence of complications, and increase the degree of clinical attention.