The purpose of this study was to analyze the clinical experience of Zan Qiang, a famous doctor of Traditional Chinese Medicine in Shaanxi province, in the treatment of perimenopausal osteoporosis. Zan believed that the main etiology and pathogenesis of perimenopausal osteoporosis were "deficiency of kidney essence, decreased marrow and bone", "deficiency of liver and kidney" and "stasis caused by deficiency". Although it is a chronic physiological disease, and the pathological process is irreversible, the treatment groups of "tonifying kidney and filling essence", "tonifying liver and tonifying kidney" and "tonifying deficiency and promoting blood circulation" can significantly improve the symptoms of patients, slow down the progress of the disease and improve the quality of life of patients.