As a famous traditional Chinese medicine (TCM) expert in Shandong province and a famous veteran TCM expert in Dezhou city, Zhang Hongxing has been engaged in cardiovascular clinical work for more than 30 years. He has unique experience in the treatment of refractory angina pectoris. This paper comprehensively explains from the aspects of etiology and pathogenesis. His treatment is mostly based on syndrome differentiation, combined with the basic pharmacology of modern Chinese medicine to formulate prescriptions and drugs, and at the same time values the use of insect drugs. We hereby attach the clinical records, hoping to provide reference for clinical workers, which is conducive to the inheritance and development of famous Chinese medical academic experience.