Objective: The paper was to analyze the investigation and study of the psychological status of children and adolescents during the epidemic period of COVID-19. Methods: From March 5th to 11th, 2020, 1766 students from 8 to 18 years old in Yan'an area were taken as the research objects, and the psychological characteristics of this group of people during the epidemic period of COVID-19 were analyzed by the online questionnaires. Results: In the questionnaire, all children and adolescents were in good psychological conditions, and they had not shown serious negative psychological emotions, and they attached great importance to COVID-19. Conclusion: The psychological changes of children and adolescents during the epidemic period of COVID-19 are diverse. Most children and adolescents have a good mental state, and a few have negative psychological emotions. It can strengthen the psychological management of children and adolescents during the epidemic, and promote the healthy growth of children and adolescents clinically.