Objective: To explore the effect and value of transvaginal ultrasound in screening early ectopic pregnancy. Methods: A total of 146 patients with ectopic pregnancy in our hospital were selected. The patients' entry time was from May 2018 to December 2020. 146 patients were divided into two groups. The control group was screened by abdominal ultrasound with 73 cases, and the experimental group was screened by vaginal ultrasound with 73 cases. The uterine adnexal mass, pelvic effusion, peritoneal effusion and diagnostic accuracy were detected. Results: The positive number of abdominal ultrasound was significantly higher than that of vaginal ultrasound; In the detection process of abdominal ultrasound, 54 cases of ectopic pregnancy, 19 cases of non-ectopic pregnancy, the detection rate was 73.97%, 26 cases of ectopic pregnancy, 47 cases of non-ectopic pregnancy, the detection rate was 32.62%. Conclusion: The accuracy of transvaginal ultrasound is relatively high, and the accuracy of ectopic pregnancy examined by transvaginal ultrasound is higher, which is more friendly to patients, less traumatic and high operability. It can provide more accurate reports for patients and relieve the psychological pressure of patients, which is worthy of application in actual screening.