Objective: This paper mainly explores the effect of fine management application in maintenance of deep venous indwelling catheter in hemodialysis patients. Methods: 150 hemodialysis patients with deep venous catheter indwelling in our hospital from December 2019 to September 2020 were divided into routine group and study group. The routine group was given routine nursing, and the study group was given fine management nursing. The nursing effect of the two groups was analyzed. Results: After nursing intervention, the incidence of complications in the study group was 14.66%, which was lower than that in the conventional group (53.33%), and the nursing compliance in the study group (98.66%) was higher than that in the conventional group (89.33%), all P < 0.05. Conclusion: Fine management plays a significant role in the maintenance of deep venous indwelling catheter in hemodialysis patients, which can reduce the occurrence of complications.