Objective: To observe and analyze the perioperative nursing effect of plasma radiofrequency ablation for treatment of lumbar disc herniation. Methods: A total of 100 patients with lumbar intervertebral disc herniation received from October 2017 to October 2020 were selected and randomly divided into two groups with 50 cases in each group. The control group received the conventional nursing model and the experimental group received the comprehensive nursing model. The two groups of nursing care were compared on satisfaction, SDS and SAS scores before and after treatment, VAS score and JOA score before and after treatment, and treatment effect. Results: The nursing satisfaction of the experimental group, SDS and SAS scores before and after treatment, VAS score and JOA score before and after treatment, and the treatment effect were better than those of the control group. The difference was statistically significant (P<0.05). Conclusion: The comprehensive nursing model has a significant effect on the perioperative nursing of the treatment of lumbar intervertebral disc herniation by plasma radiofrequency ablation. More popularization and application will help improve the treatment effect.