Objective: To evaluate and analyze the clinical effect of group intervention combined with massage nursing in patients with lymphedema. Methods: The time span of this study was selected from October 2017 to December 2020. A total of 496 patients with lymphedema after breast cancer surgery were included. They were divided into study group and control group according to the difference of nursing intervention scheme. The control group was given basic nursing, and the study group was given Satya group intervention combined with massage nursing. The indicators of the two groups were compared and analyzed. Results: Compared with the two groups at different time points, the study group had more advantages (P< 0.05). Compared with the recurrence rate of lymphedema in the two groups, the study group had more advantages (P< 0.05);Compared with the sads score and SES score after nursing intervention, the study group had more advantages (P< 0.05).Conclusion: The clinical effect of group intervention combined with massage nursing in patients with lymphedema is significant, which can be promoted in all levels of medical institutions.