Acute Guillain Barre syndrome is a common type of autoimmune mediated acute peripheral neuropathy. Its initial symptoms are symmetrical limb weakness, sensory disturbance, pain or other symptoms. This paper reports a case of acute Guillain Barre syndrome in a uremic patient with diabetic nephropathy and long-term regular hemodialysis, in order to further explore the clinical manifestations and differential characteristics of uremic patients with acute Guillain Barre syndrome, improve the early diagnosis rate of uremic patients with acute Guillain Barre syndrome, make the patients get timely treatment, so as to reduce the disability of such patients To improve the prognosis of the disease.