Keywords
Case report
Hepatic cystic solid mass
Published : 2026-08-16
Abstract
Undifferentiated embryonal sarcoma of the liver (UESL) is rare in adults, and its clinical manifestations, laboratory tests, and imaging findings lack specificity. Diagnosis relies on pathological diagnosis. This article reports a 55-year-old male patient with UESL who was admitted to the hospital due to right upper abdominal pain for 3 months. He had no history of chronic hepatitis or cirrhosis, and the tumor marker was only elevated CA-125. CT showed a huge cystic solid exogenous mass in the right lobe of the liver. The patient underwent right hemihepatectomy due to tumor rupture and bleeding. Postoperative pathology confirmed UESL, and genetic testing revealed FGFR2 amplification and TP53 mutation. This disease needs to be differentiated from hepatocellular carcinoma and liver abscess. Surgical resection is the preferred treatment, and postoperative combined chemotherapy can effectively improve prognosis.
References
Pu T, Chen J, Guo Q, et al., 2021, Surgical Diagnosis and Treatment of Adult Huge Undifferentiated Embryonal Sarcoma of the Liver. Zhonghua Wai Ke Za Zhi, 59: 848–853.
Gerson G, Valença J, Cavalcante J, et al., 2019, Undifferentiated Embryonal Sarcoma of the Liver in Elderly: Case Report and Review of the Literature. Indian Journal of Pathology and Microbiology, 62: 129–131.
Zhang C, Jia C, Xu C, et al., 2020, Undifferentiated Embryonal Sarcoma of the Liver: Clinical Characteristics and Outcomes. World Journal of Clinical Cases, 8: 4763–4767.
Putra J, Ornvold K, 2015, Undifferentiated Embryonal Sarcoma of the Liver: A Concise Review. Archives of Pathology & Laboratory Medicine, 139(2): 269–273.
Ziogas I, Zamora I, Lovvorn H, et al., 2021, Undifferentiated Embryonal Sarcoma of the Liver in Children Versus Adults: A National Cancer Database Analysis. Cancers (Basel), 13(12): 2918.
Cao W, Qiu B, 2012, A Case of Undifferentiated Embryonal Sarcoma of the Adult Liver and Literature Analysis. Chinese Journal of Clinical Physicians (Electronic Edition), 6(17): 5360–5361.
Wu M, Yu K, Shu J, 2020, One Case of Undifferentiated Embryonal Sarcoma of the Adult Liver. Chinese Journal of Modern Medicine, 22(12): 80–81.
Xu X, Luo B, 2013, Ultrasound Findings of Undifferentiated Embryonal Sarcoma in Adult Liver: A Case Report. Chinese Medical Imaging Technology, 29(8): 1408.
Qiu G, Liao W, Wen Z, et al., 2021, Imaging Manifestations of Undifferentiated Embryonal Sarcoma in Adult Liver. CT Theory and Applications, 30: 114–123.
Martins-Filho S, Putra J, 2020, Hepatic Mesenchymal Hamartoma and Undifferentiated Embryonal Sarcoma of the Liver: A Pathologic Review. Hepatic Oncology, 7(2): Hep19.
Liu S, Yang Y, Li B, 2025, Misdiagnosed as Hepatocellular Carcinoma in One Case of Undifferentiated Embryonal Sarcoma of the Adult Liver. Chinese Journal of CT and MRI, 23(9): 209–211.
Department of Medical Administration, National Health Commission of the People's Republic of China, 2024, Diagnosis and Treatment Guidelines for Primary Liver Cancer (2024 Edition). Liver Cancer Electronic Journal, 11: 1–26.
Lin W, Wu K, Chen C, et al., 2024, Treatment of Undifferentiated Embryonal Sarcoma of the Liver in Children. Cancers (Basel), 16(5): 897.
Lou J, Li G, Lv J, et al., 2026, One Case of Undifferentiated Embryonal Sarcoma of the Liver Misdiagnosed as Liver Abscess and Literature Review. Chinese Journal of CT and MRI, 24: 199–201.
Lenze F, Birkfellner T, Lenz P, et al., 2008, Undifferentiated Embryonal Sarcoma of the Liver in Adults. Cancer, 112: 2274–2282.
Wu Z, Wei Y, Cai Z, et al., 2020, Long-Term Survival Outcomes of Undifferentiated Embryonal Sarcoma of the Liver: A Pooled Analysis of 308 Patients. ANZ Journal of Surgery, 90: 1615–1620.
Capozza M, Ruggiero A, Maurizi P, et al., 2019, Undifferentiated Embryonal Sarcoma of the Liver (UESL) in Adolescents: An Unexpected Diagnosis. Journal of Pediatric Hematology/Oncology, 41: e132–e134.