Keywords
Unstable angina pectoris
Qi deficiency and blood stasis syndrome
Clinical efficacy
Submitted : 2026-05-31
Accepted : 2026-06-15
Published : 2026-06-30
Abstract
Objective: To analyze and evaluate the therapeutic effect of Yiqi Huoxue Formula on patients with unstable angina pectoris of Qi deficiency and blood stasis syndrome. Methods: A total of 95 patients with unstable angina pectoris admitted to our hospital from January to December 2025 were selected for the study. They were randomly divided into a control group (47 cases) and an observation group (48 cases) using a random number table. The control group received conventional Western medicine intervention, while the observation group was additionally treated with Yiqi Huoxue Formula. The changes in traditional Chinese medicine (TCM) syndrome scores, clinical efficacy, angina symptom scores, inflammatory markers, cardiac troponin I (cTnI), and the discontinuation or reduction rate of nitroglycerin tablets were compared between the two groups. Results: Compared with the control group, the TCM syndrome scores in the observation group significantly decreased after treatment (p < 0.05). The total effective rates in the observation and control groups were 93.75% and 76.60%, respectively (p < 0.05). Compared with before treatment, the angina symptom scores in both groups decreased after treatment, with a greater reduction observed in the observation group (p < 0.05). Compared with the control group, the observation group had lower levels of IL-6, hs-CRP, and cTnI after treatment (p < 0.05). The total discontinuation or reduction rates of nitroglycerin in the observation and control groups were 79.17% and 53.19%, respectively (p < 0.05). Conclusion: For patients with unstable angina pectoris of Qi deficiency and blood stasis syndrome, the addition of Yiqi Huoxue Formula to Western medicine treatment can effectively alleviate their clinical symptoms and reduce TCM syndromes, reduce inflammatory responses and myocardial injury levels, enhance clinical efficacy, and help reduce nitroglycerin usage, demonstrating good clinical application value.
References
Xia H, Liu D, Zhang M, et al., 2025, Levels of Soluble Programmed Cell Death Ligand 1 in Patients with Unstable Angina and Its Correlation with Prognosis. Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 27(2): 149–153.
National Center for Cardiovascular Diseases, The Writing Committee of the Report on Cardiovascular Health and Diseases in China, 2024, China Cardiovascular Health and Disease Report 2023: An Overview. Chinese Circulation Journal, 39(7): 625–660.
National Health Commission of the People’s Republic of China, 2022, China Health Statistics Yearbook. Beijing: Peking Union Medical College Press.
Cai N, Li Y, 2025, Efficacy Analysis of Simvastatin Combined with Xuesaitong Dropping Pills in the Treatment of Unstable Angina. China Prescription Drug, 23(9): 106–109.
Ma Z, Wang F, Lu J, et al., 2026, Clinical Study on Xinnao Liantong Capsule Combined with Diltiazem Hydrochloride Tablets in the Treatment of Stable Angina. China Medicine, 21(1): 93–97.
Nie H, Li Y, Lu P, et al., 2021, Efficacy of YiQi Huoxue Decoction Combined with High-Dose Atorvastatin in the Treatment of Unstable Angina with Qi-yin Deficiency Syndrome and Its Effect on Serum Inflammatory Factor Levels. Journal of Modern Integrative Traditional Chinese and Western Medicine, 30(24): 2689–2692 + 2736.
Yu K, Zeng Q, 2024, Interpretation of the “Guidelines for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndrome (2024)”. Journal of Clinical Cardiology, 40(9): 697–700.
Zhang R, Su H, Huang X, et al., 2022, Expert Consensus on the Diagnosis and Treatment of Unstable Angina in Traditional Chinese Medicine. Journal of Traditional Chinese Medicine, 63(7): 695–700.
Wei X, Lu J, Gu N, 2025, Comparative Study on the Clinical Efficacy of Different Dosage Forms of Wendan Decoction in the Treatment of Unstable Angina. Lishizhen Medicine and Materia Medica Research, 36(20): 3901–3908.
Li Z, Wu Y, Cui J, et al., 2022, Retrospective Analysis of YiQi Huoxue Decoction in the Treatment of Unstable Angina After Percutaneous Coronary Intervention. World Journal of Traditional Chinese Medicine, 17(5): 731–735.
Wu Y, Fu C, Luo C, et al., 2021, Effect of Panax Notoginseng Saponins on Inflammatory Response in Rats with Acute Cerebral Infarction by Regulating the cGAS/STING/NF-κB Pathway. Beijing Journal of Traditional Chinese Medicine, 40(10): 1061–1065.