Research Review on Early Diagnostic Markers and Intervention Strategies for Liver Fibrosis

Abstract

Liver fibrosis represents a pivotal intermediate pathological stage in the progression from various chronic liver diseases to cirrhosis and hepatocellular carcinoma, characterized primarily by persistent hepatocyte injury leading to the activation of hepatic stellate cells, which subsequently results in excessive extracellular matrix deposition and hepatic tissue structural remodeling. Early-stage liver fibrosis is fully reversible; however, once it advances to late-stage fibrosis or cirrhosis, the difficulty of reversal significantly increases. Therefore, early and accurate diagnosis, coupled with timely intervention, is crucial for improving the prognosis of patients with chronic liver diseases and reducing mortality from end-stage liver diseases. This article systematically reviews current markers for the early diagnosis of liver fibrosis and summarizes mainstream intervention strategies, providing theoretical references and clinical practice evidence for the early diagnosis and treatment of liver fibrosis.