Objective: To investigate the application effect of predictive and targeted nursing in patients with liver cirrhosis complicated with upper gastrointestinal bleeding, and to evaluate its impact on clinical indicators, psychological state, and quality of life of patients. Methods: A total of 102 patients with liver cirrhosis complicated with upper gastrointestinal bleeding who were hospitalized from January 2023 to December 2023 were selected and divided into a control group (51 cases) and an observation group (51 cases) according to the random number table method. The control group received routine care, while the observation group received further strengthening of preventive care and targeted care on the basis of routine care. Clinical indicators (time to stop bleeding, length of hospital stay, incidence of rebleeding), psychological states (Self-Rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS) scores), and quality of life (Short Form SF-36 score) were compared between the two groups. Results: The hemostasis time and hospital stay in the observation group were shorter than those in the control group, and the incidence of rebleeding was also lower than that in the control group, which was statistically significant (p < 0.05). After the intervention, the SAS and SDS scores of the observation group were lower than those of the control group, and the scores of each dimension of the SF-36 scale were higher than those of the control group, and the differences were statistically significant (p < 0.05). Conclusion: The application of predictive and targeted nursing to patients with liver cirrhosis complicated with upper gastrointestinal bleeding can significantly shorten hemostasis and hospital stay, reduce the incidence of rebleeding, significantly improve patients’ anxiety and depression, improve patients’ quality of life, and has good clinical application value.
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