Keywords
Intensive care unit (ICU)
Risk factors
Multivariate logistic regression
Submitted : 2026-04-19
Accepted : 2026-05-04
Published : 2026-05-19
Abstract
Objective: This study aimed to identify risk factors for subsyndromal delirium (SSD) in adult intensive care unit (ICU) patients using a multivariate logistic regression model. Methods: A total of 252 ICU patients admitted to a Grade A tertiary hospital between January 2024 and December 2025 were included in the study. General characteristics, clinical conditions, treatments and laboratory test results were compared between 174 patients who developed SSD and 78 who did not. Univariate risk factors for SSD were identified, and multivariate logistic regression analysis was performed to determine the independent risk factors for SSD. Results: Multivariate logistic regression analysis revealed that patient age (OR = 1.465), Acute Physiology and Chronic Health Evaluation II (APACHE II) score (OR = 1.677), Critical Care Pain Observation Tool (CPOT) score (OR = 1.899), physical restraint (OR = 3.485), sepsis (OR = 2.452) and duration of mechanical ventilation (OR = 1.635) were identified as independent risk factors for SSD in ICU patients. Conclusion: Elderly ICU patients are at higher risk of developing sub-delirium syndrome; early screening and timely medical intervention can reduce the risk of SSD and improve patient prognosis.
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