Objective: To explore the treatment of Morita therapy combined with transcranial magnetic stimulation in postpartum depression of primipara and its effect on prolactin. Method: From May 2018 to November 2019, 92 cases of postpartum depression and postpartum women who were treated in our hospital were randomly divided into 2 groups, 46 cases each. The control group was treated with transcranial magnetic stimulator, and the observation group was treated with Morita therapy on the basis of the control group. Both groups were treated continuously for 6 weeks. The degree of depression and prolactin levels of the two groups was observed. Result: After 6 weeks of treatment, the HAMD scores of the two groups were lower than before the treatment, and the observation group was the lowest. The prolactin levels of the two groups were higher than before the treatment, and the observation group was the highest. The difference was statistically significant(P<0.05). Conclusion: Morita therapy combined with transcranial magnetic stimulation can effectively improve the postpartum depression of primiparas, increase the level of prolactin, and have a good clinical effect.