Nurse-Led Early Enteral Nutrition Tolerance Management Protocol for Patients with Severe Traumatic Brain Injury: A Quasi-Experimental Study
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Keywords

Severe traumatic brain injury
Enteral nutrition
Feeding intolerance
Nurse-led care
Tolerance management
Neurocritical care

DOI

10.26689/jcnr.v10i5.14673

Submitted : 2026-05-31
Accepted : 2026-06-15
Published : 2026-06-30

Abstract

Objective: To evaluate the efficacy of a nurse-led early enteral nutrition (EN) tolerance management protocol in reducing feeding intolerance and improving nutritional outcomes among patients with severe traumatic brain injury (STBI). Methods: A total of 128 STBI patients admitted to the neurosurgical intensive care unit between June 2024 and June 2025 were enrolled. The control group  received conventional EN care from June to December 2024, while the intervention group  received the nurse-led protocol from January to June 2025. The primary outcomes were feeding intolerance incidence, target caloric achievement rate on day 4, nocturnal feeding prevalence, and ICU length of stay. Results: The incidence of feeding intolerance was significantly lower in the intervention group compared to the control group . The intervention group demonstrated higher target caloric achievement rates on day 4  and day 7 . Nocturnal feeding was significantly reduced , and ICU length of stay was shorter .Conclusion: The nurse-led early EN tolerance management protocol effectively reduces feeding intolerance, enhances early nutritional adequacy, minimizes nocturnal feeding disruptions, and shortens ICU stay for STBI patients.

References

Chinese Society of Neurosurgery, 2022, Chinese Expert Consensus on Early Rehabilitation Management of Severe Traumatic Brain Injury (2022 Edition). Chin J Neurosurg, 38(6): 541–551.

Li L, Wang X, Li C, 2020, Research Progress on Early Enteral Nutrition Support in Patients with Severe Traumatic Brain Injury. Chin J Nurs, 55(3): 456–460.

McClave S, Taylor B, Martindale R, et al., 2016, Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: SCCM and A.S.P.E.N. JPEN J Parenter Enteral Nutr, 40(2): 159–211.

Reintam Blaser A, Starkopf J, Alhazzani W, et al., 2017, Early Enteral Nutrition in Critically Ill Patients: ESICM Clinical Practice Guidelines. Intensive Care Med, 43(3): 380–398.

Zhang Y, Yang L, Wang X, 2019, Meta-analysis of Risk Factors for Enteral Nutrition Feeding Intolerance in ICU Patients. Chin Nurs Manag, 19(8): 1181–1187.

Xu L, Li Q, Han B, 2021, Application of Nurse-led Nutrition Support Management Model in ICU Patients. J Nurs Sci, 36(12): 97–100.

Padar M, Uusvel G, Starkopf J, et al., 2019, Implementation of a Nurse-driven Enteral Nutrition Protocol in an Intensive Care Unit: A Before-and-after Study. J Clin Nurs, 28(23–24): 4384–4392.

Zhou M, Zhang C, Tian Y, 2020, Development and Validation of a Feeding Intolerance Assessment Scale for Critically Ill Patients. Chin Crit Care Med, 32(9): 1097–1101.

Reintam Blaser A, Malbrain M, Starkopf J, et al., 2012, Gastrointestinal Function in Intensive Care Patients: Terminology, Definitions and Management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive Care Med, 38(3): 384–394.

Liu F, Zhao H, Sun J, 2022, Application of Nurse-led Enteral Nutrition Tolerance Management in Neurocritical Patients. Chin J Pract Nurs, 38(15): 1145–1150.

Wang Z, Zhang L, Chen W, et al., 2021, A Nurse-led Enteral Nutrition Tolerance Management Protocol for Critically Ill Patients: A Quasi-experimental Study. J Adv Nurs, 77(8): 3426–3435.

Chen L, Wang F, Li P, 2020, Research Progress on Gastrointestinal Dysmotility Mechanism and Nursing Intervention in Severe Traumatic Brain Injury Patients. J Nurses Train, 35(14): 1276–1279.

Sun Q, Wang X, 2019, Application Progress of Short-peptide Enteral Nutrition Formulations in Critically Ill Patients. Parenter Enteral Nutr, 26(5): 311–314.

Yang X, Wu G, 2018, Biological Rhythms and Enteral Nutrition: From Basic to Clinical. Chin J Gastrointest Surg, 21(12): 1428–1432.

Wei X, Day A, Ouellette D, et al., 2019, The Association Between Nutritional Adequacy and 28-day Mortality in the Critically Ill. Crit Care, 23(1): 323.

Zhang H, Li L, Wang Y, 2020, Effect of Early Enteral Nutrition on Prognosis of Severe Traumatic Brain Injury Patients. Chin J Trauma, 36(5): 432–437.

Voigt R, Forsyth C, Keshavarzian A, 2019, Circadian Rhythms: A Regulator of Gastrointestinal Health and Dysfunction. Expert Rev Gastroenterol Hepatol, 13(5): 411–424.

Heyland D, Stephens K, Day A, et al., 2011, The Success of Enteral Nutrition and ICU-acquired Infections: A Multicenter Observational Study. Clin Nutr, 30(2): 148–155.