Keywords
Ischemic cardiomyopathy
Regulatory mechanism
Targeted therapy
Submitted : 2026-03-08
Accepted : 2026-03-23
Published : 2026-04-07
Abstract
Ischemic cardiomyopathy (ICM) is the terminal manifestation of long-term myocardial ischemia, necrosis, and fibrosis caused by coronary artery disease, and its pathogenesis involves multiple modes of cell death. In recent years, the role of ferroptosis as an iron dependent, lipid peroxidation driven regulatory form of cell death in ICM has gradually been revealed. This article systematically reviews the molecular mechanisms of ferroptosis and its role in the occurrence and development of ICM, and explores potential therapeutic strategies targeting ferroptosis, aiming to provide new ideas for the prevention and treatment of ICM.
References
Knuuti J, Wijns W, Saraste A, et al., 2020, ESC Guidelines for the Diagnosis and Management of Chronic Coronary Syndromes. European Heart Journal, 41: 407–477.
Felker G, Shaw L, O’Connor C, 2002, A Standardized Definition of Ischemic Cardiomyopathy for Use in Clinical Research. Journal of the American College of Cardiology, 39(2): 210–218.
Khan M, Hashim M, Mustafa H, et al., 2020, Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. Cureus, 12: e9349.
Chang X, Toan S, Li R, et al., 2022, Therapeutic Strategies in Ischemic Cardiomyopathy: Focus on Mitochondrial Quality Surveillance. EBioMedicine, 84.
Liu H, Xu Y, Liu Y, et al., 2024, Identification of Novel Ferroptosis-Related Biomarkers Associated with Oxidative Stress Pathways in Ischemic Cardiomyopathy. International Journal of Cardiology Heart and Vasculature, 56: 101584.
Dixon S, Lemberg K, Lamprecht M, et al., 2012, Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death. Cell, 149(5): 1060–1072.
Conrad M, Pratt D, 2019, The Chemical Basis of Ferroptosis. Nature Chemical Biology, 15(12): 1137–1147.
Li J, Cao F, Yin H, et al., 2020, Ferroptosis: Past, Present and Future. Cell Death and Disease, 11(2): 88.
Chen X, Li J, Kang R, et al., 2021, Ferroptosis: Machinery and Regulation. Autophagy, 17(9): 2054–2081.
Cui Y, Zhu X, Zhang Q, et al., 2025, Research Progress on the Role and Mechanism of Ferroptosis in Heart Disease. Chinese Journal of Physiology, 77(1): 75–84.