Keywords
Long bones of the extremities
PRP
Complication rate
Fracture healing
Submitted : 2026-01-14
Accepted : 2026-01-29
Published : 2026-02-13
Abstract
Objective: To analyze the clinical application value of autologous periosteum graft combined with platelet-rich plasma (PRP) in the treatment of long bone fractures in the extremities. Methods: A total of 40 patients with long bone fractures in the extremities admitted to Santai Hospital Affiliated to North Sichuan Medical College from January 2023 to January 2025 were included, including cases of upper extremity forearm fractures and lower extremity femoral and tibial fractures. The patients were evenly divided using a random number table, with the control group undergoing open reduction and internal fixation (ORIF) combined with autologous periosteum graft, and the observation group undergoing ORIF, autologous periosteum graft, and PRP injection. Surgical indicators, complication rates, excellent fracture healing rates, functional satisfaction, and joint range of motion were compared between the two groups. Results: The surgical indicators in the observation group were similar to those in the control group (p > 0.05). The complication rate in the observation group was lower than that in the control group, while the excellent fracture healing rate and functional satisfaction were higher in the observation group (p < 0.05). Conclusion: Autologous periosteum graft combined with PRP technology is safe and reliable for the treatment of long bone fractures in the extremities, with satisfactory clinical outcomes.
References
Ma Y, Liu Y, Chen C, et al., 2021, Autologous Iliac Bone Graft with Periosteum for the Treatment of Severe Talar Cartilage Injury. Chinese Journal of Trauma, 37(7): 635–640.
Gao Y, Zhou J, Liu Y, et al., 2022, Primary Flap Transplantation Combined with Secondary Tibial Periosteal Flap and Autologous Bone Graft for the Treatment of Gustilo Type III B and III C Tibial Bone and Soft Tissue Defects. Chinese Journal of Bone and Joint Injury, 37(12): 1266–1270.
He W, Lv Z, Yang W, et al., 2021, Efficacy of Autologous Iliac Bone Graft with Periosteum in the Treatment of Hepple Type V Talar Osteochondral Injury. Chinese Journal of Bone and Joint Injury, 36(10): 1031–1034.
Xiang S, Sun Q, Su Y, et al., 2022, Autologous Iliac Bone Graft, Pedicled Periosteal Flap Transfer, and External Fixation for Nonunion after Internal Fixation of Femoral Shaft Fractures. Chinese Journal of Bone and Joint Injury, 37(10): 1079–1081.
Dong X, Sun Q, Su Y, et al., 2022, Autologous Cancellous Bone with Platelet-Rich Plasma Implantation Combined with Vascularized Pedicled Periosteal Flap Transfer for Scaphoid Nonunion with Osteonecrosis. Chinese Journal of Hand Surgery, 38(1): 16–20.
Huang C, Liao D, Ren Y, et al., 2021, Locking Plate Internal Fixation Combined with Autologous Iliac Bone Graft for Neer Type III and IV Proximal Humeral Fractures. Chinese Journal of Bone and Joint Injury, 36(9): 981–983.
Tu J, Huang X, Li X, et al., 2025, Platelet-Rich Plasma Injection at the Fracture Site Combined with Microfracture for Delayed Fracture Healing. Chinese Journal of Blood Transfusion, 38(2): 194–200.
Abuduheilili·Maimaitiaili M, Wang J, Aikeremujiang·Aierken A, et al., 2025, Effects of PFNA Internal Fixation Combined with Platelet-Rich Plasma Injection on Hemorheology, Fracture Healing, and Joint Function in Intertrochanteric Fractures. Journal of Translational Medicine, 14(4): 53–57.
Hong Y, Chen S, Yue S, 2025, Effects of Ultrasound-Guided Platelet-Rich Plasma Injection on Residual Pain, Bone Mineral Density, and Bone Metabolism after Vertebroplasty in Osteoporotic Vertebral Compression Fractures. Journal of Cervicodorsal Pain, 46(6): 1064–1069.
Wang J, Zhang W, Wang Z, et al., 2025, Effects of Early Intra-Articular Platelet-Rich Plasma Injection on Inflammatory Factors and Knee Function after Schatzker Type V and VI Tibial Plateau Fractures. Chinese Journal of New Clinical Medicine, 18(5): 550–554.