Objective: To explore the interventional room nursing and its application effects in patients with ischemic stroke treated with tirofiban combined with direct thrombectomy. Methods: A total of 61 patients with ischemic stroke admitted to our hospital from June 2024 to June 2025 were selected and divided into two groups using the red and blue ball method: the control group (n = 30, receiving routine interventional room nursing) and the observation group (n = 31, receiving additional tirofiban medication-specific nursing + individualized interventional nursing on the basis of routine nursing). The cerebral hemodynamic indicators, adverse reactions, effectiveness of complication nursing, and nursing satisfaction were compared between the two groups. Results: After 7 days of treatment, the observation group had lower cerebrovascular peripheral resistance and higher mean blood flow velocity and mean blood flow volume compared to the control group (all p < 0.05). The observation group had a higher effectiveness rate of complication nursing than the control group, with a statistically significant difference (p < 0.05). The nursing satisfaction in the observation group (96.77%) was higher than that in the control group (80.00%), with a statistically significant difference (χ2 = 4.223, p = 0.040 < 0.05). Conclusion: Tirofiban combined with direct thrombectomy can significantly improve cerebral hemodynamics, enhance the effectiveness of complication nursing, and increase patient satisfaction in patients with ischemic stroke.
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