Keywords
Acute pancreatitis
Infectious pancreatic necrosis
Submitted : 2025-12-16
Accepted : 2025-12-31
Published : 2026-01-15
Abstract
Objective: To analyze the value of prophylactic antibiotic use in reducing the incidence of pancreatic necrosis in patients with emergency acute pancreatitis (AP). Methods: A total of 70 AP patients who sought medical attention from January 2024 to January 2025 were randomly divided into groups by drawing lots. Group A received prophylactic antibiotic intervention, while Group B received conventional intervention. Results: Group A demonstrated superior outcomes compared to Group B in terms of therapeutic efficacy, duration of symptoms, inflammatory factors, symptom scores, and complication rates, with p < 0.05. Conclusion: Prophylactic antibiotic treatment in emergency AP patients leads to a decrease in inflammatory factor levels, alleviation of symptoms, a reduction in the incidence of infectious pancreatic necrosis, and is safe and effective.
References
Li L, Liu Y, Zhang R, et al., 2021, Study on the Prevention of Infections in Severe Acute Pancreatitis with Carbapenem Antibiotics. Journal of Surgery: Principles and Clinical Practice, 26(4): 348–352.
Huang M, Yu W, Xiao X, et al., 2024, The Impact of Prophylactic Administration of Ulinastatin on Acute Pancreatitis Following Endoscopic Retrograde Cholangiopancreatography. Fujian Medical Journal, 46(4): 59–62.
Song R, Song X, Li S, 2024, Exploration of Clinical Treatment for Acute Pancreatitis in Emergency Internal Medicine. Medical Journal of Chinese Science and Technology Periodical Database, 2024(3): 13–16.
Yu J, Wu X, 2024, Integrated Traditional Chinese and Western Medicine Treatment Strategies for Severe Acute Pancreatitis in the Acute Phase. Chinese Journal of Integrative Surgery on Liver and Pancreatobiliary Diseases, 30(4): 456–461.
Yang J, 2024, Publication of “Integrated Traditional Chinese and Western Medicine Treatment for Acute Pancreatitis”: Understanding and Treatment of Acute Pancreatitis in Modern Medicine and Traditional Chinese Medicine. Journal of Interventional Radiology, 33(5): 4.
Guo H, Feng W, 2024, Observation of the Clinical Effects of Gastrointestinal Department Treatment for Patients with Acute Pancreatitis. Medical Journal of Chinese Science and Technology Periodical Database, 2024(3): 69–72.
Gu S, 2023, Clinical Efficacy of Prophylactic Antibiotic Treatment for Acute Pancreatitis. Contemporary Medicine, 29(11): 131–133.