Objective: To explore the clinical efficacy of plastic surgery of asymmetric double eyelid. Methods: The clinical data of 70 patients with asymmetrical double eyelid who underwent plastic surgery in our hospital from April 2018 to December 2019 were retrospectively analyzed. The patients were divided into different groups based on different plastic surgery procedures. The control group (n=35 cases) were the patients who underwent double eyelid incision method, and the patients who used embedding double eyelid method were included in the observation group (n=35 cases). The operation time, intraoperative blood loss, incision size, healing time of incision, satisfaction of plastic surgery and occurrence of complications were compared between the two groups. Results: The operation time and incision healing time of the observation group were shorter than those of the control group. The intraoperative blood loss and incision were less than those of the control group, and the satisfaction was higher than that of the control group. The difference was statistically significant (P<0.05). The incidence of complications in the observation group was slightly lower than the control group, but the difference was not statistically significant (P>0.05). Conclusion: For asymmetric double eyelid, it should undergo embedding double eyelid plastic surgery, because the operation time and incision healing time are shorter. And intraoperative blood loss and incision size are smaller, which can improve patient satisfaction and reduce the incidence of complications.