Objective: To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome (CPPS). Methods: A total of 95patients with CPPS from the Department of Urology, First Affiliated Hospital of Jinan University, were selected and treated with electrophysiological therapy. They were randomly divided into three groups: the fixed-parameter AA7 treatment group, the P2 + P4 treatment group, and the precision treatment group (individualized parameter treatment). Pain scores of patients in each group were compared before and after treatment, with a pain score of 0 indicating cure. The cure rate of each group was observed. Results: The average ages of the AA7 group, P2 + P4 group, and precision treatment group were 34 ± 14.17 years, 35.58 ± 12.57 years, and 35.5 ± 11.27 years, respectively. There was no significant difference in age among the three groups (p > 0.05). Before treatment, the pain scores of the AA7 group, P2 + P4 group, and precision treatment group were 4.14 ± 1.74, 4.64 ± 1.72, and 3.50 ± 1.89, respectively, with no significant differences among the groups (p > 0.05). After treatment, the pain scores were 0.71 ± 0.99 for the AA7 group (cure rate: 57%), 0.49 ± 0.79 for the P2 + P4 group (cure rate: 67%), and 0.50 ± 0.77 for the precision treatment group (cure rate: 64%), with no significant differences among the groups (p > 0.05). The cure rates for different pain locations were as follows: 83% for lower abdominal pain, 74% for perineal pain, 62% for dysuria, 49% for testicular pain, and 75% for inguinal pain. Conclusion: The pathogenesis of CPPS is complex and diverse, with numerous treatment options and uncertain efficacy, posing significant challenges to clinical practice. This study showed that electrophysiological therapy under different parameter modes significantly reduced pain scores before and after treatment, indicating significant therapeutic effects on CPPS. All three modes demonstrated good cure rates. Individualized precision treatment and fixed-mode P2 + P4 or AA7 treatment were safe and effective in CPPS treatment and are worth promoting. Fixed-mode P2 + P4 and AA7, due to their easier standardization of parameters and patch modes, reduced the learning curve and had better potential for widespread application.
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