Analysis of the Efficacy of High-Flow Nasal Cannula Oxygen Therapy and Non-Invasive Ventilation in COPD Patients
Abstract
Patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) often suffer from respiratory failure and require respiratory support therapy. High-flow nasal cannula oxygen therapy (HFNC) and non-invasive positive pressure ventilation (NIPPV) are commonly used non-invasive respiratory support methods. HFNC can provide precisely heated and humidified high-flow oxygen, reducing dead space and increasing alveolar ventilation. NIPPV can supply stable high-concentration oxygen and improve gas exchange. This article reviews the application of HFNC and NIPPV in the acute exacerbation stage of COPD, aiming to provide references for reasonable clinical selection.
References
Wang S, Jia J, 2025, Clinical Study on the Treatment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Using Han Chuan Zu Pa Granules. Shanxi Medical Journal, 54(05): 368–371.
Liu J, Zhang S, Huang S, et al., 2021, Procalcitonin-Guided Antibiotic Therapy in AECOPD Patients: Overview of Systematic Reviews. Clinical Respiratory Journal, 15(6): 579–594.
Zhang L, Tong P, Gu C, et al., 2025, Correlation of Serum IL-1β and HBP With the Prognosis of Non-Invasive Positive Pressure Ventilation Treatment in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated by Respiratory Failure. Medical Journal of Communications, 39(03): 226–231.
Xue Y, Du J, Shu Y, et al., 2025, Detection Rate of Pulmonary Infections and Logistic Regression Analysis in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Journal of Public Health and Preventive Medicine, 36(02): 43–46.
Hao J, 2025, Clinical Effect of Budesonide/Formoterol/Glycopyrronium Combined with Ambroxol in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Chinese and Foreign Medical Research, 23(14): 27–30.
Huang X, Guo C, Liu S, et al., 2025, Clinical Efficacy of HFNC in the Treatment of COPD Complicated with Respiratory Failure. Clinical Rational Drug Use, 18(05): 166–168.
Jiang X, Zhou G, 2023, Evaluation of the Effect of Nasal High-Flow Oxygen Therapy as an Adjunct in the Treatment of Severe Pneumonia Complicated with Respiratory Failure. Shanghai Medical and Pharmaceutical Journal, 44(06): 23–26.
Wang C, Meng Y, Chang Y, et al., 2023, Analysis of the Efficacy of Nasal High-Flow Humidified Oxygen Therapy at Different Flow Rates in Patients with Postoperative Hypoxemia. International Journal of Anesthesiology and Resuscitation, 44(04): 370–374.
Ren Y, Lu Q, Yu C, 2024, Clinical Efficacy of Nasal High-Flow Humidified Oxygen Therapy in Chronic Obstructive Pulmonary Disease Complicated with Type II Respiratory Failure. Clinical Research, 32(12): 77–81.
Wang P, 2024, Observation on the Efficacy of Nasal High-Flow Oxygen Therapy in Elderly Patients with Respiratory Failure. Smart Healthcare, 10(29): 99–101.
Yang Y, 2022, Clinical Efficacy of Nasal High-Flow Humidified Oxygen Therapy and Non-Invasive Positive Pressure Ventilation in the Treatment of Chronic Obstructive Pulmonary Disease Complicated with Type 2 Respiratory Failure. Medical Equipment, 35(02): 76–78.
Yuan G, Chen W, 2024, Clinical Efficacy of Alternating Use of Nasal High-Flow Oxygen Therapy and Non-Invasive Positive Pressure Ventilation in Elderly Patients with Severe Pneumonia and Respiratory Failure. Clinical Medical Research and Practice, 9(29): 63–66.
Jiang J, Chen B, Ke B, et al., 2022, Clinical Efficacy of Non-Invasive Ventilation in the Treatment of Patients with Chronic Obstructive Pulmonary Disease. China Health Standards Management, 13(06): 88–91.
Huang G, Zhou J, Xiao Y, et al., 2022, Evaluation of the Effect of Non-Invasive Mechanical Ventilation Combined with Nasal High-Flow Therapy in the Treatment of Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure. Shanghai Medical and Pharmaceutical Journal, 43(20): 25–28.
Cao C, Liu Z, Hu X, et al., 2024, Study on the Clinical Efficacy of Nasal High-Flow Humidified Oxygen Therapy in the Treatment of Patients with Acute Heart Failure Complicated with Respiratory Failure. China Practical Medicine, 19(21): 44–47.
Liu H, 2023, Application of High-Flow Nasal Cannula Oxygen Therapy Combined with Non-Invasive Ventilation in Patients with COPD Requiring Mechanical Ventilation. Heilongjiang Medicine and Pharmacy Journal, 46(05): 148–150.
Sun P, Tong X, Wu J, et al., 2024, Application of High-Flow Nasal Cannula Oxygen Therapy Combined with Sequential Non-Invasive Ventilation in Initial Ventilation Strategies for AECOPD. Medical Innovations of China, 21(23): 28–33.
Shi L, Xu N, Zhang C, 2024, Clinical Application of Non-Invasive Positive Pressure Ventilation and High-Flow Nasal Cannula Oxygen Therapy in the Treatment of AECOPD With Respiratory Failure. Journal of Rare and Uncommon Diseases, 31(12): 48–50.
Li Z, 2021, Clinical Effects of High-Flow Nasal Cannula Oxygen Therapy, Non-Invasive Positive Pressure Ventilation, and Their Combined Use in the Treatment of Elderly Patients with Severe Pneumonia and Respiratory Failure. Medical Nutrition and Health, 19(18): 87–88.
