Objective: Research on nursing method of artificial liver support system applied in severe hepatitis patients. Methods: Selected 50 severe hepatitis patients in our hospital during the period of January 2018 and January 2019, observed and analyzed the clinical intervention effect of all treated by artificial liver support system cooperating with related nursing methods. Results: After the treatment, the clinical symptoms and abdominal distension of the patients were relieved, whose spirit took a turn for the better and the jaundice subsided. Among these patients, 68% got improved enough to be released, 26.00% gave up for financial concerns and 6.00% died. Before and after treatment, the patients’ PT and PTA improved obviously, and the difference were quite a lot (P<0.05), while ALT and ALB showed few without any statistical significance (P>0.05). Conclusion: During the treatment and intervention of severe hepatitis patients with artificial liver support system, effective nursing interventions are needed, mainly including completely preoperative, intraoperative and postoperative care so as to ensure the treatment effect and promote the recovery of intervention, which has remarkable significance to clinical development.