Objective: To manage the safety management of nursing drugs.Methods: 120 patients were randomly divided into two groups:the management group and the control group. The control group was treated with routine medication. The management group was treated with drug safety management on the basis of the management group. And the values of the two groups were compared. Results: The treatment effect and nursing satisfaction were higher in the management group than in the control group, and the error rate was lower than that of the control group (P <0.05). Conclusion: Nursing medication in patients with cardiology in nursing care to take safety management measures. It can strengthen the treatment of patients and nursing effects, worthy of promotion.