Objective: To analyze the effect of interventional nursing on the therapeutic effect, negative emotion and quality of life of patients undergoing cardiovascular and cerebrovascular interventional therapy. Methods: Eighty-four patients who received cardio-cerebral vascular interventional therapy in a hospital during January 2024–December 2024 were selected, and were divided into the control group and the observation group by the mean score method, each with 42 cases. The control group was given standardized perioperative care, and the observation group was given interventional nursing intervention on this basis. The two groups were compared in terms of clinical efficacy, negative emotion score, incidence of related complications, quality of life score and nursing satisfaction. Results: The total effective rate of treatment of patients in the observation group (95.24%) was significantly higher than that of the control group (78.57%), and the difference was statistically significant (P < 0.05); before nursing care, the difference between SDS and SAS scores of patients in the two groups was insignificant (P > 0.05); after nursing care, the scores of various indexes of the two groups were significantly reduced and the observation group was lower than that of the control group, and the difference was statistically significant (P < 0.05); the patients in the observation group had more negative moods than those in the control group; the complication rate of patients in the observation group (2.38%) was significantly lower than that of the control group (19.04%), and the difference was statistically significant (P < 0.05); the quality of life scores of patients in the observation group were higher than that of the control group, and the difference was statistically significant (P < 0.05); the satisfaction rate of patients’ nursing care in the observation group was 97.62%, which was higher than that of the control group (78.57%), and the difference was statistically significant (P < 0.05). The difference is statistically significant (P < 0.05). Conclusion: The implementation of interventional nursing intervention for patients with cardiovascular and cerebrovascular interventional therapy can further enhance the clinical therapeutic effect, improve the negative emotions of patients’ anxiety and depression, reduce the risk of related complications, improve the quality of life of patients, and obtain higher satisfaction.
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