Keywords
Hypertension
EGFR decline ratio
Non-intervention
Submitted : 2025-06-10
Accepted : 2025-06-25
Published : 2025-07-10
Abstract
Objective: As the prevalence of chronic diseases among the elderly increases year by year, chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world. Methods: This article conducted a retrospective analysis of 1856 elderly people over 65 years old, with a follow-up time of 6 years. The aim is to compare the decline in estimated glomerular filtration rate (EGFR) between hypertensive and non-hypertensive populations under non-intervention conditions, and to explore the impact of blood pressure on EGFR in the elderly. Results: The incidence of hypertension among the elderly in this region is significantly higher than the national level. The EGFR value of hypertensive patients is significantly lower than that of non-hypertensive people. There is a difference in the percentage decline in EGFR between hypertensive and non-hypertensive populations under non-intervention conditions, with hypertensive patients experiencing a higher rate of EGFR decline. When blood pressure is lower than 120/80 mmHg, the EGFR decline ratio is lower compared to when blood pressure is higher than 120/80 mmHg. Conclusion: Lowering blood pressure can effectively slow down the decline of EGFR, and the prevalence of hypertension should be reduced.
References
Chen WW, Gao RL, Liu LS, et al., 2017, Summary of the 2016 Report on Cardiovascular Diseases in China. Chinese Circulation Journal, 32(6): 521–530.
Fang JY, Guo ZH, Fu HC, et al., 2023, Changes in Hypertension Prevalence Among Adult Residents in Yunnan Province From 2015 to 2021. Chin J Prev Contr Chron Dis, 31(6): 411–415.
Zhang L, Long J, Jiang W, et al., 2016, Trends in Chronic Kidney Disease in China. N Engl J Med, 375(9): 905–906.
Yi CX, Zhao YJ, Zhang CY, et al., 2024, Analysis of Influencing Factors of Peripheral Vascular Injury in Hypertensive Patients in Yunnan Province. China Journal of Modern Medicine, 34(4): 78–83.
Zhao YJ, 2017, Early Diagnostic Value of Urinary NGAL Level Detection in Renal Function Damage of Patients With Primary Hypertension. Shandong Medical Journal, 57(17): 67–69.
Beijing Hypertension Prevention and Treatment Association, Chinese Stroke Association Hypertension Prevention and Management Branch, 2024, Chinese Guidelines for the Prevention and Treatment of Hypertension (2024 Revision), China.
Yu J, Tian AJ, Yuan X, et al., 2015, Study on the Correlation Between Serum Uric Acid Level and Early Renal Function Damage in Hypertensive Patients. Laboratory Medicine and Clinic, 12(19): 2948–2950.
Yi QH, Shen AX, Zhang GH, et al., 2021, Comparative Analysis of the Incidence and Compliance Rate of Chronic Diseases Among People Over 60 Years Old in a Certain Area. Yunnan Medical Journal, 2021(01): 83–85.
Su JF, Zhao L, Tang K, et al., 2015, Analysis of Drug Influencing Factors on Changes in Serum Creatinine After Admission in a Patient With Type 2 Diabetes Mellitus Complicated With Hypertension and Renal Insufficiency. Evaluation and Analysis of Drug Use in Chinese Hospitals, 15(5): 627–630.
Xu L, 2017, Analysis of Renal Function Changes and Influencing Factors One Year After PCI in Patients With Acute Coronary Syndrome and Hypertension. International Medicine and Health Guidance News, 23(10): 1507–1510.
Li ZB, Jin ZD, Chen HH, 2016, Risk Factor Analysis of Hypertension and Renal Function Decline in Patients With Simple Renal Cyst. Guangdong Medical Journal, 37(6): 868–870.
Wang H, Hu YH, Wu HQ, et al., 2016, Analysis of Differences in Blood Lipids and Renal Function and Influencing Factors of Blood Pressure in Different Types of Hypertensive Populations and Healthy Populations. Chinese Journal of Evidence-Based Cardiovascular Medicine, 8(11): 1308–1312.
Zhang M, Wu J, Zhang X, et al., 2021, Study on the Prevalence and Control Status of Hypertension Among Chinese Adults in 2018. Chinese Journal of Epidemiology, 42(10): 1780–1789.
Cheng L, Guo ZH, 2024, Research on the Current Status of Medical and Health Information Services for Elderly Hypertensive Patients in Yunnan Province. Yunnan Medical Journal, 2024(03): 47–50.
Marrone O, Cibella F, Pépin JL, et al., 2018, Fixed but Not Auto-Adjusting Positive Airway Pressure Attenuates the Time-Dependent Decline in Glomerular Filtration Rate in Patients With OSA. Chest, 154(2): 326–334. DOI: 10.1016/j.chest.2018.04.020.
Rimke AN, Ahmed SB, Turin TC, et al., 2019, Effect of CPAP Therapy on Kidney Function in Patients With Obstructive Sleep Apnea and Chronic Kidney Disease: A Protocol for a Randomised Controlled Clinical Trial. BMJ Open, 9(3): e024632. DOI: 10.1136/bmjopen-2018-024632.