Keywords
Betahistine mesylate
Tianma Gouteng Decoction
Efficacy
Submitted : 2025-06-08
Accepted : 2025-06-23
Published : 2025-07-08
Abstract
Objective: To evaluate the therapeutic effect of Tianma Gouteng Decoction combined with Betahistine Mesylate in patients with posterior circulation ischemic vertigo (PCI). Methods: Eighty-two patients with PCI who visited the hospital from February 2024 to February 2025 were selected as samples and randomly divided into two groups. Group A received Tianma Gouteng Decoction combined with Betahistine Mesylate, while Group B received only Betahistine Mesylate. The efficacy, syndrome scores, hemodynamics, and quality of life indicators were compared between the two groups. Results: The efficacy of PCI treatment in Group A was higher than that in Group B (P < 0.05). The syndrome scores in Group A were lower than those in Group B (P < 0.05). The peak systolic velocity (PSV) of the basilar artery and left and right vertebral arteries in Group A were higher than those in Group B (P < 0.05). The quality of life (SF-36) score in Group A was higher than that in Group B (P < 0.05). Conclusion: Tianma Gouteng Decoction combined with Betahistine Mesylate is effective and feasible in the treatment of PCI, with improved hemodynamic indicators and reduced disease scores.
References
Song S, Li Y, Yang C, 2024, Observation on the Therapeutic Effect of Modified Tianma Gouteng Decoction Combined with Western Medicine in Treating Acute Ischemic Stroke with Hypertension of Liver Yang Hyperactivity Type. China Prescription Drug, 22(9): 155–158.
Chinese Expert Consensus Group on Posterior Circulation Ischemia, 2006, Chinese Expert Consensus on Posterior Circulation Ischemia. Chinese Journal of Internal Medicine, 45(9): 786–787.
Wang X, Liu C, Li B, Qiao Y, 2023, Therapeutic Effect of Modified Tianma Gouteng Decoction Combined with Xingnao Kaiqiao Acupuncture on Posterior Circulation Ischemic Vertigo and Its Influence on sCD40L, ET-1, and NSE Levels. Sichuan Journal of Traditional Chinese Medicine, 41(3): 120–123.
Zhou Z, Zhou J, 2022, Clinical Effect of Tianma Gouteng Decoction Combined with Betahistine Mesylate in Treating Posterior Circulation Ischemic Vertigo and Its Effect on Improving Cerebral Blood Flow Velocity. Clinical Research of Traditional Chinese Medicine, 14(20): 105–108.
Cui Y, Sun Y, Liu D, 2024, Effect of Xuesaitong Combined with Betahistine Mesylate in the Treatment of Patients with Posterior Circulation Ischemic Vertigo. Heilongjiang Medicine and Pharmacy Sciences, 47(2): 128–131.
Zhong H, Li F, Zhai R, et al., 2024, Analysis of the Effect of Betahistine Mesylate Combined with Edaravone Dexborneol in the Treatment of Patients with Posterior Circulation Ischemic Vertigo. Chinese Journal of Trauma and Disability Medicine, 32(15): 36–39.
Zhu M, Li R, Wu X, 2024, Effects of Qidiligui Decoction Combined with Betahistine Mesylate on TCM Syndrome Scores and Cerebral Hemodynamics in Patients with Posterior Circulation Ischemic Vertigo. Heilongjiang Medicine and Pharmacy Sciences, 47(6): 73–77.
Qin X, Jiang X, 2024, Clinical Effect of Butylphthalide Combined with Betahistine Mesylate in the Treatment of Patients with Posterior Circulation Ischemic Vertigo. Clinical Medical Research and Practice, 9(27): 50–53.
Li H, Li S, Wang Y, et al., 2024, Observation on the Effect of Cinepazide Maleate Combined with Betahistine Mesylate in the Treatment of Patients with Posterior Circulation Ischemic Vertigo. Big Doctor, 9(23): 121–124.
Li G, Wang L, Sang J, et al., 2024, Effects of Danhong Injection Combined with Betahistine Hydrochloride on Vertigo Symptoms, Blood Lipids, and Hemorheological Indices in Patients with Posterior Circulation Ischemic Vertigo. China Modern Medicine, 31(31): 41–45.
Wu D, Guo X, Xie L, 2022, Effect of Modified Tianma Gouteng Decoction in Treating Posterior Circulation Ischemic Vertigo of Liver Yang Hyperactivity Type. Medical Information, 35(17): 148–150.