Objective: To explore the construction and application value of a home skin care guidance program for neonates. Methods: From February 2024 to February 2025, 60 neonates were selected as samples and randomly grouped by drawing. Group A received the constructed home skin care program for neonates, while Group B received routine care. The mastery of skin care knowledge by parents, emotional scores of mothers, and adverse reaction rates of neonates were compared. Results: The mastery of skin care knowledge by parents in Group A was higher than that in Group B, P < 0.05. The anxiety (SAS) and depression (SDS) scores of mothers in Group A were lower than those in Group B, P < 0.05. The adverse reaction rate of neonates in Group A was lower than that in Group B, P < 0.05. Conclusion: The construction of a home skin care program for neonates can reduce adverse reactions of mothers, improve parents’ mastery of neonatal skin care knowledge, and is beneficial for reducing adverse events such as neonatal eczema, diaper dermatitis, and infection.
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