Keywords
Blood purification
Adverse reactions
Submitted : 2025-06-10
Accepted : 2025-06-25
Published : 2025-07-10
Abstract
Objective: To observe and explore the effectiveness and safety of continuous blood purification intervention in the clinical treatment of patients with severe sepsis in the Intensive Care Unit (ICU). Methods: Medical records were collected from March 2024 to March 2025, including a total of 54 patients with severe sepsis in the ICU. The patients were divided into two groups using a random number table method: the conventional group (27 patients receiving conventional treatment) and the observation group (27 patients receiving continuous blood purification in addition to conventional treatment). C-reactive protein, arterial lactate, mean arterial pressure, respiration, and heart rate were measured. The Sequential Organ Failure Assessment (SOFA) score was compared, and adverse reactions were observed. Results: The observation group had lower levels of C-reactive protein, arterial lactate, respiration, heart rate, and total SOFA score compared to the conventional group, while the mean arterial pressure was higher (P < 0.05). The incidence of adverse reactions during treatment was lower in the observation group than in the conventional group (P < 0.05). Conclusion: The use of continuous blood purification in the clinical treatment of patients with severe sepsis in the ICU is effective. It can alleviate the disease, improve vital signs, reduce inflammatory damage, and reduce adverse reactions.
References
Ji W, Meng Y, Bo L, et al., 2021, Interpretation of the Save Sepsis Campaign: International Guidelines for the Treatment of Sepsis and Infectious Shock, 2021 Edition. Chinese Journal of Anaesthesiology, 41(12): 1409–1413.
Yuan C, Song H, 2020, Prognostic Predictive Value of Acute Physiological and Chronic Health Status Scores and Sequential Organ Failure Assessment in Patients With Sepsis. Nursing Practice and Research, 17(21): 70–72.
Luo W, He L, 2020, Clinical Efficacy and Safety Evaluation of Continuous Blood Purification Applied to the Treatment of Severe Sepsis in ICU. Systemic Medicine, 5(24): 49–51.
Zhang J, 2023, Observation on the Efficacy of Continuous Blood Purification in Patients With Sepsis. Chinese Health Care, 41(1): 149–152.
Tang R, Qi P, Wang H, et al., 2024, Changes in Serum STIM1 and sP-Selectin Levels in Patients With Sepsis Treated With Continuous Blood Purification and the Relationship With Prognosis. Chinese Journal of Emergency Resuscitation and Disaster Medicine, 19(10): 1323–1326.
Zheng L, 2022, Clinical Effect of Continuous Blood Purification in the Treatment of Severe Sepsis and Its Influence on Patients’ Immune Function. Clinical Medicine Research and Practice, 7(29): 85–87.
Lin Y, 2023, Analysis of the Effects of Continuous Blood Purification Therapy on Nitric Oxide Synthase and Calcitoninogen in Patients With Systemic Inflammatory Response Syndrome and Sepsis. Chinese General Medicine, 26(S1): 47–50.
Huang J, 2023, Effects of Continuous Blood Purification for Severe Sepsis on Patients’ Haemodynamics and Inflammatory Factor Levels. Electronic Journal of Modern Medicine and Health Research, 7(6): 36–38.
Li S, Ouyang M, Wu H, et al., 2021, Effect of Continuous Blood Purification Therapy on Blood Lactate and Inflammatory Factor Levels in Patients With Severe Sepsis. Huaihai Medicine, 39(6): 613–615.
Zhou H, 2021, Clinical Effect and Safety of Continuous Blood Purification in the Treatment of Severe Sepsis. Journal of Clinical Rational Use of Drugs, 14(29): 160–162.