Keywords
Aspirin
Labetalol
Blood pressure
Submitted : 2025-06-10
Accepted : 2025-06-25
Published : 2025-07-10
Abstract
Objective: To evaluate the effect of labetalol combined with aspirin on improving blood pressure in patients with hypertensive disorders of pregnancy (HDP). Methods: Eighty-two patients with HDP who visited the hospital from August 2022 to August 2024 were selected as samples and randomly divided into two groups. Group A was treated with labetalol and aspirin, while Group B was treated with labetalol only. The efficacy, blood pressure, vascular endothelial function, coagulation indexes, and pregnancy outcomes were compared between the two groups. Results: The efficacy of Group A was higher than that of Group B (P < 0.05). The systolic blood pressure (SBP), diastolic blood pressure (DBP), and endothelin-1 (ET-1) in Group A were lower than those in Group B (P < 0.05). The prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen (FIB) in Group A were all better than those in Group B (P < 0.05). The rate of adverse pregnancy outcomes in Group A was lower than that in Group B (P < 0.05). Conclusion: The combination of labetalol and aspirin for the treatment of HDP can stabilize blood pressure, optimize vascular endothelial function, improve coagulation indexes and pregnancy outcomes, which is highly effective and feasible.
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