Objective: To explore the intervention value of the medical institution prescription review mechanism on the rationality of Western medicine use. Methods: A total of 159 patients (with 159 western medicine prescriptions) admitted to the hospital from January 2023 to December 2024 were selected and divided into an observation group (n=80, adopting the medical institution prescription review mechanism) and a control group (n=79, without prescription review) based on the random number table method. A comparative analysis was conducted on the work quality of medical personnel, irrational prescription drug use, and prescription drug dispensing situations. Results: The work quality of medical personnel in the observation group was significantly better than that in the control group (P < 0.05). The incidence of irrational prescription drug use in the observation group (22.50%) was significantly higher than that in the control group (7.59%) (P < 0.05). The observation group had fewer types of prescribed drugs, lower usage rates of injections and antibiotics, and a significantly higher usage rate of national essential drugs compared to the control group (P < 0.05). Conclusion: The prescription review mechanism can significantly improve the work quality of medical personnel, increase the detection rate of irrational drug use, reduce the types of prescription drugs and the use of injections and antibiotics, and promote the standardized application of national essential drugs, which has important intervention value.
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