Keywords
Carbohydrate antigen 125
Molecular markers
Submitted : 2025-06-04
Accepted : 2025-06-19
Published : 2025-07-04
Abstract
Objective: To investigate the expression level of carbohydrate antigen 125 (CA125) in threatened miscarriage and explore its significance in the auxiliary diagnosis of threatened miscarriage. Method: Pregnant women who underwent prenatal examinations in the hospital from June 2023 to June 2024 were collected. Among them, 66 cases were clinically diagnosed with threatened miscarriage and 74 cases had early normal pregnancies. The expression levels of CA125 in the serum of the above research subjects and the HCG levels of pregnant women with different pregnancy conditions were compared. Result: The expression level of CA125 in the threatened abortion group (119.0 ± 23.37) was significantly higher than that in the normal pregnancy group (57.15 ± 5.554), and the difference was significant (p < 0.05). Clinical data analysis showed that the expression level of human chorionic gonadotropin (HCG) in the threatened abortion group (11690 ± 2337) was significantly lower than that in the normal pregnancy group (36130 ± 6855), and there was a significant difference between the two (p < 0.05); The expression level of progesterone (P) in the threatened abortion group was also significantly lower than that in the normal pregnancy group (P < 0.05). Conclusion: CA125 is abnormally expressed in the serum of pregnant women with threatened miscarriage and can be used as a molecular marker for the auxiliary diagnosis of threatened miscarriage. Regular detection of the concentration of CA125 in the serum of pregnant women can provide a reference for clinical assessment of decidual damage and can be used as an auxiliary basis for predicting the risk of threatened miscarriage.
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