Objective: The effects of combined dexmedetomidine hydrochloride and propofol in minimally invasive axillary odor surgery with tumescent anesthesia. Methods: A total of 46 patients underwent minimally invasive axillary odor surgery by tumescent anesthesia received in the hospital from May 2017 to January 2019 were divided into observation group (23 cases) and control group (23 cases) according to the random number table method. The control group used propofol, and the observation group underwent minimally invasive axillary odor combined with dexmedetomidine hydrochloride by tumescent anesthesia. The changes of arterial blood pressure (MAP), heart rate (HR) and postoperative complications before and after anesthesia were compared and analyzed between the two groups. Results: After anesthesia, MAP and HR in both groups were lower than before anesthesia, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). Compared with the control group, the postoperative complications were less in the observation group, but the difference was not statistically significant (P>0.05). Conclusion: Compared with the use of propofol, the effect of dexmedetomidine hydrochloride combined with minimally invasive axillary odor surgery by tumescent anesthesia is more obvious, and the postoperative recovery is faster with fewer complications.