In recent years, with the continuous expansion of China's infrastructure construction, related construction work, including highway and bridge construction, has been steadily progressing. Among them, bridges are an important component of infrastructure construction, and their safety and stability are related to the travel of the masses and even the safety of their lives. China has a strict management system for bridge design specifications. This article mainly takes long-span highway bridges as an example to study the key issues of its design specifications and proposes countermeasures for related work.