Driven by both digital healthcare and educational intelligence, nursing majors in private universities are confronted with the core contradiction between talent cultivation and clinical needs. Taking the application of artificial intelligence (AI) technology as the entry point, this study analyzes the existing deficiencies in nursing education of private universities and combines practical cases from Yongzhou Vocational and Technical College, Shandong Xiehe College, etc. It constructs a “demand perception–intelligent decision-making–dynamic optimization” professional adjustment mechanism, proposes a “three-stage and three-dimensional” curriculum reconstruction system, and discusses the implementation guarantee paths. The research results show that with the empowerment of AI, the matching degree of nursing professional courses can be increased by 37%, and the excellent rate of students’ clinical decision-making ability can be improved by 42%, which provides a practical example for the digital transformation of nursing education in private universities.
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