Keywords
ZNF304
TRIM28
Epigenetics
Epithelial-mesenchymal transition
Submitted : 2026-01-26
Accepted : 2026-02-10
Published : 2026-02-25
Abstract
Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, and its development involves complex genetic and epigenetic mechanisms. Epigenetic regulation, especially DNA methylation, plays a crucial role in tumorigenesis, progression, and metastasis. Epithelial-mesenchymal transition (EMT) is an important process promoting tumor cell invasion and metastasis, and epigenetic regulators such as TRIM28 and ZNF304 play key roles in this process. TRIM28 can regulate the expression of EMT-related genes by activating the TGF-β signaling pathway and histone modification; ZNF304, as a member of the C2H2 zinc finger transcription factor family, is closely related to cell survival, migration, and metastasis in various tumors. This review summarizes the epigenetic regulatory mechanisms of TRIM28 and ZNF304 in colorectal cancer, exploring their roles in the EMT process and tumor migration and invasion, providing new insights for the study of colorectal cancer metastasis mechanisms and targeted therapy.
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