Safety Analysis of Umbilical Vein Puncture Guided by B-Ultrasound in Prenatal Diagnosis
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B-ultrasound guidance
Umbilical vein puncture
Prenatal diagnosis



Submitted : 2024-01-28
Accepted : 2024-02-12
Published : 2024-02-27


Objective: To explore the safety of umbilical vein puncture guided by B-ultrasound in prenatal diagnosis. Methods: Patients undergoing prenatal examinations in the Department of Obstetrics and Gynecology from February 2023 to February 2024 were selected as the observational subjects. A total of 90 cases were included. Umbilical vein puncture was performed under B-ultrasound guidance to observe puncture safety. Results: The one-time puncture success rate of umbilical vein puncture under B-ultrasound guidance in 90 patients was 97.78%, with an average puncture time of 8.43 ± 1.04 minutes. Fetal heart rate slowed down in 2 cases during umbilical vein puncture guided by B-ultrasound and in 3 patients after surgery, resulting in an incidence rate of 5.56%. Logistic nonlinear multifactor analysis indicated that puncture time and the number of successful punctures were correlated. Additionally, fetal cardiovascular system abnormalities emerged as an independent risk factor for fetal heart rate slowdown, with a statistical value of P < 0.05. Conclusion: The one-time success rate of umbilical vein puncture guided by B-ultrasound for prenatal diagnosis is high. Early identification of high-risk groups and the implementation of targeted measures can reduce puncture adverse events and ensure the safety of prenatal diagnosis.


Yang D, Li M, Yu Q, et al., 2023, Analysis of the Results of 413 Cases of Prenatal Diagnosis of Invasive Chromosomes in Twin Pregnancies. Chinese Medical Journal, 58(11): 1214–1217.

Wei L, Long X, Zheng H, et al., 2022, Analysis of Complications and Treatment Strategies of Ultrasound-Guided Transabdominal Prenatal Diagnostic Puncture. Imaging Research and Medical Applications, 6(13): 191–193.

Luo Y, Zhao B, Sun Y, et al., 2022, Analysis of Prenatal Diagnosis Results and Pregnancy Outcomes of High-Risk Fetuses Through Non-Invasive Prenatal Screening. Chinese General Medicine, 25(20): 2482–2488.

Gao Y, 2020, Analysis of the Relationship between Prenatal B-Ultrasound Screening Abnormalities, Fetal Chromosomal Abnormalities and Pregnancy Outcomes. Modern Diagnosis and Treatment, 31(22): 3619–3621.

Zou Q, Xiong A, Li Q, et al., 2022, Application of Amniocentesis Under B-Ultrasound Guidance in Prenatal Diagnosis. Contemporary Medicine, 28(7): 25–27.

Wang D, Man T, Jiang L, et al., 2020, Analysis of Risk Factors for Fetal Heart Rate Slowdown Caused by Ultrasound-Guided Percutaneous Umbilical Venipuncture. Chinese Family Planning and Obstetrics and Gynecology, 12(4): 33–37.

Gong L, 2022, Study and Explore the Nursing Experience Related to Prenatal Diagnosis Through Abdominal Umbilical Venipuncture. Smart Health, 2022(18): 145–148.

Hou L, Wang X, Liu L, et al., 2022, Analysis of Prenatal Diagnosis Results of 134 Cases of Growth Restricted Fetuses. Journal of Capital Medical University, 2022(3): 375–379.

Xu G, Deng Y, 2023, Research Progress in Non-Invasive Prenatal Diagnosis of Thalassemia Based on Fetal Cell-Free DNA. Journal of Medical Postgraduate Studies, 2023(7): 771–774.

Zhang R, 2023, Application of Umbilical Vein Catheterization Combined with Central Venous Catheter Inserted Through Peripheral Veins in the Treatment of Premature Infants. Maternal and Child Health Guide, 2(21): 61–63.

Zhao F, Fu Z, Yan Y, et al., 2023, Prenatal Ultrasound Diagnosis of Missing Venous Ductus and Analysis of Pregnancy Outcomes. Journal of Fudan University: Medical Edition, 50(2): 255–261.

Li W, Huang X, Ye Y, 2022, Genetic Study of a Family with 3M Syndrome Combined with Netherton Syndrome. Journal of Molecular Diagnosis and Therapy, 14(11): 2009–2013.

Wang Y, Li H, Zhao M, et al., 2022, Application of 3D-PDA and MPI in Prenatal Diagnosis and Prediction of Pregnancy Outcomes in Pregnant Women with Velamentous Placenta. Chongqing Medicine, 2022(8): 1297–1299.

Tan L, Huang T, Zou Y, et al., 2023, Study on the Correlation between Chromosome 17q12 Microdeletion Syndrome and Fetal Kidney Echo Enhancement. Jiangxi Medicine, 58(1): 7–11.

Song M, 2021, Clinical Application Value of Prenatal B-Ultrasound in Diagnosing Fetal Umbilical Cord Around the Neck. Marriage, Parenting and Health, 2021(21): 135–136.