Effect of Vitamin E Supplemented with Calcium in the Treatment of Hypertension During Pregnancy on Maternal and Infant Outcomes
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Keywords

Hypertension during pregnancy
Vitamin E
Calcium supplements
Maternal and infant outcomes

DOI

10.26689/aogr.v1i2.5213

Submitted : 2023-08-22
Accepted : 2023-09-06
Published : 2023-09-21

Abstract

Objective: To investigate the effect of vitamin E supplemented with calcium in the treatment of hypertension during pregnancy on maternal and infant outcomes. Methods: 60 patients with gestational hypertension admitted from January 2020 to December 2022 were recruited and randomly divided into the control group and the observation group, each group including 30 patients. The control group was given routine treatment, whereas the observation group was given routine treatment combined with vitamin E-supplemented calcium therapy, and both groups received treatment until delivery. The clinical effects of the observation group and the control group after treatment, systolic and diastolic blood pressure, mean arterial pressure, urine protein, blood lipid levels at different time points (before and after treatment), and maternal and child outcomes during treatment were uniformly compared and analyzed. Results: After treatment, the total clinical effective rate (93.33%) of the observation group was significantly higher than that of the control group (70.00%); compared with before treatment, the systolic blood pressure, diastolic blood pressure, mean arterial pressure, urine protein, TC, and TG levels of the two groups were all lower after treatment, and the observation group was at a lower level; there was no significant difference in the incidence of hemorrhage (P > 0.05). Conclusion: Vitamin E supplemented with calcium has a significant effect on the treatment of hypertension during pregnancy, which can help reduce blood pressure and blood lipid levels, reduce urinary protein content, improve maternal and child outcomes, and improve safety.

References

Zhu Y, Yu Z, Kan C, et al., 2020, Clinical Efficacy of Nifedipine Sustained-Release Tablets Combined with Labetalol in the Treatment of Hypertension During Pregnancy and Its Effect on Serum LAP and APN Levels. Chinese Modern Applied Pharmacy, 37(22): 2775–2779.

Wang Z, Zhou T, 2022, The Curative Effect of Nifedipine Combined with Labetalol in the Treatment of Hypertension During Pregnancy and Its Effect on Serum Adiponectin Level and Blood Viscosity. Chinese Journal of Family Planning, 30(7): 1577–1581.

Niu H, Wu N, Wang S, et al., 2021, Efficacy of Magnesium Sulfate Combined with Aspirin in the Treatment of Hypertensive Disorder During Pregnancy and Its Effect on the Levels of Superoxide Dismutase and Endothelin-1. Chinese Journal of Family Planning, 29(2): 284–287.

Ming N, Liu Z, Wu H, et al., 2022, Comparison of the Effects of Magnesium Sulfate and Nifedipine on Hemodynamics and Pregnancy Outcomes in Pregnant Women with Hypertensive Disorders in Pregnancy. Journal of Practical Clinical Medicine, 26(14): 84–87.

Zhou N, Zhou B, Gao M, 2020, Evaluation of the Curative Effect of Low-Dose Aspirin Combined with Calcium and Vitamin E in the Treatment of Hypertensive Disorders During Pregnancy. Chinese Journal of Family Planning, 28(3): 349–352.

Group of Obstetrics and Gynecology Branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of hypertensive disorders in pregnancy (2015). Chinese Journal of Obstetrics and Gynecology, 2015, 50(10): 721-728.

Wang J, Yuan D, Zhao J, 2021, Risk Factors of Hypertensive Disorders During Pregnancy and Their Impact on Maternal and Infant Prognosis. Chinese Maternal and Child Health Care, 36(21): 5025–5027.

Wu Q, Zhao T, Wang Z, et al., 2023, Risk Factors for Hypertensive Disorders During Pregnancy and the Impact of Disease Severity on Pregnancy Outcomes. Clinical Military Medical Journal, 51(3): 288–290 + 293.

Xu X, Yang B, 2022, Effects of Magnesium Sulfate Combined with Nifedipine on Coagulation Function and Pregnancy Outcome in Patients with Hypertensive Disorders of Pregnancy. Thrombosis and Hemostasis, 28(2): 264–265 + 267.

Zhang Y, Chen D, Shen M, 2021, Effects of Vitamin E Combined with Labetalol on Serum S100-B Protein, hs-CRP and PAPP-A Levels in Patients with Gestational Hypertension. Journal of Clinical and Experimental Medicine, 20(13): 1423–1426.

Lin X, 2022, Efficacy of Nifedipine Combined with Vitamin E in the Treatment of Pregnancy-Induced Hypertension. Cardiovascular Disease Prevention Knowledge, 12(6): 11–13.

He F, 2021, Clinical Characteristics of Glucose and Lipid Metabolism Indexes in Pregnant Women with Hypertensive Disorder During Pregnancy and Their Influence on Maternal and Infant Pregnancy Outcomes. China Maternal and Child Health Care, 36(16): 3694–3697.

He Y, 2021, Effects of Hypertensive Disorders in Pregnancy on Pregnancy Outcomes in Elderly Women. Chinese Maternal and Child Health Care, 36(11): 2488–2489.

Xu X, Li J, 2019, Analysis of Curative Effect and Pregnancy Outcome of Vitamin E Supplemented with Calcium in the Treatment of Pregnancy-Induced Hypertension. Journal of Hunan Normal University (Medical Edition), 16(5): 38–40.