Objective: To analyze the therapeutic effect of Guishen Yugong Decoction + sequential hormone (estrogen and progesterone) replacement therapy and its effect on serum sex hormones in patients with premature ovarian failure. Methods: From July 2020 to July 2022, 100 patients with premature ovarian failure were included in the study. Random number table method was used to divide the patients into groups: the control group received sequential hormone replacement therapy, whereas the treatment group received Guishen Yugong Decoction + sequential hormone replacement therapy. The curative effect, traditional Chinese medicine (TCM) syndrome scores, serum sex hormone levels, and incidence of adverse reactions of both groups of patients were compared. Results: The total effective rate in the treatment group was higher than that in the control group, P < 0.05; the TCM syndrome scores in the treatment group were lower than those in the control group, P < 0.05; the serum sex hormone indices in the treatment group were better than those in the control group (P < 0.05); the treatment group had lower incidence of adverse reactions, as compared to the control group (P < 0.05). Conclusion: Guishen Yugong Decoction + sequential hormone replacement therapy can regulate serum sex hormone levels and relieve symptoms of premature ovarian failure. This treatment is not only effective, but also safe for clinical use.
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