Keywords
Magnesium sulfate
Pregnancy-induced hypertension
Clinical effect
Renal function
Pregnancy outcome
Submitted : 2024-02-18
Accepted : 2024-03-04
Published : 2024-03-19
Abstract
Objective: To investigate the effect of nifedipine + magnesium sulfate treatment on pregnancy-induced hypertension. Methods: From January 2020 to January 2023, 60 patients with pregnancy-induced hypertension in our hospital were randomly divided into the control group and the observation group (30 cases in each group). The control group was treated with magnesium sulfate, while the observation group was treated with nifedipine and magnesium sulfate, and the clinical efficacy of the two groups was compared. The effective rate of treatment, blood pressure indicators, renal function indicators, adverse pregnancy outcomes, and quality-of-life scores were investigated. Results: The effective rate of treatment and quality-of-life score in the observation group were higher than those in the control group (P < 0.05). On the other hand, the diastolic and systolic blood pressure, the 24 h urine creatinine and albumin, as well as the adverse pregnancy outcomes were found to be lower in the observation group as compared to the control group (P < 0.05). Conclusion: For patients with pregnancy-induced hypertension, treatment with nifedipine and magnesium sulfate can achieve significant curative and remarkable effects. While improving blood pressure, it can also improve renal function, optimize pregnancy outcomes, and improve quality of life.
References
Ming N, Liu Z, Wu H, et al., 2022, Comparison of the Effects of Magnesium Sulfate and Nifedipine on Hemodynamics and Pregnancy Outcomes in Pregnant Women with Hypertensive Disorders in Pregnancy. J Pract Clin Med, 26(14): 84–87.
Chen J, Qiu C, Luo Q, 2021, Effects of Magnesium Sulfate Phentolamine and Nifedipine Combined Therapy on Blood Pressure Changes and Adverse Reactions in Pregnant Women with Hypertensive Disorders During Pregnancy. Matern Child Health Care China, 36(10): 2220–2224.
Guo Y, Lei A, 2021, The Curative Effect of nifedipine combined with magnesium sulfate in the treatment of hypertension during pregnancy and its effect on the heart and kidney function of pregnant women. Guizhou Med, 45(9): 1415–1416.
Shi C. Effects of Nifedipine Combined with Magnesium Sulfate on Pregnancy Hypertension and Cardiac and Renal Function in Pregnant Women. J Pract Clin Med, 24(6): 109–112.
Fan C, 2021, Efficacy of Magnesium Sulfate Combined with Nifedipine in the Treatment of Hypertensive Disorders During Pregnancy and Its Effect on Pregnancy Outcomes. Matern Child Health Care China, 36(4): 767–770.
Wu H, Liu S, 2022, Therapeutic Effect of Magnesium Sulfate Combined with Nifedipine in Pregnancy-Induced Hypertension and Its Influence on Umbilical Blood Flow Index and Ribonuclease Inhibitory Factor. Guizhou Med, 46(2): 192–193.
Yao H, Shan W, 2022, Efficacy of Magnesium Sulfate Combined with Nifedipine in the Treatment of Hypertensive Disorders During Pregnancy and Its Impact on Pregnancy Outcomes. Reflexology Rehabil Med, 3(1): 115–118.
Xu X, Yang B, 2022, The Effect of Magnesium Sulfate Combined with Nifedipine on Coagulation Function and Pregnancy Outcome in Patients with Hypertensive Disorders of Pregnancy. J Thromb Haemost, 28(2): 264–265 + 267.
Fu J, Li N, Luo Q, et al., 2018, Effects of Nifedipine and Phentolamine Combined with Magnesium Sulfate on BNP in Patients with Pregnancy-Induced Hypertension. Hebei Med, 40(11): 1711–1713 + 1717.
Wang Y, Zhang X, 2022, Effect Analysis of Magnesium Sulfate Injection Combined with Nifedipine Treatment on Hemorheology and Inflammatory Factors in Patients with Gestational Hypertension Syndrome. Guizhou Med, 46(11): 1759–1760.
Zhou X, 2021, Analysis of the Therapeutic Effect of Magnesium Sulfate, Nifedipine Combined with Labetalol on Pregnancy-Induced Hypertension. Syst Med, 6(5): 124–126.
Jiang S, 2021, The Effect and Value of Magnesium Sulfate and Magnesium Sulfate Combined with Nifedipine in the Treatment of Pregnancy-Induced Hypertension. Marriage Health, 29(24): 172–173.
Hua W, 2021, Observation on the Effect and Safety of Nifedipine, Magnesium Sulfate Combined with Labetalol in the Treatment of Pregnancy-Induced Hypertension. Contemp Med, 27(1): 178–179.
Zhang G, 2021, Comparative Analysis of Clinical Effects of Magnesium Sulfate and Magnesium Sulfate Combined with Nifedipine in the Treatment of Patients with Pregnancy-Induced Hypertension. J Math Med, 34(4): 546–548.
Zhang X, Ma H, 2021, Clinical Efficacy of Magnesium Sulfate Combined with Nifedipine in the Treatment of Pregnancy-Induced Hypertension and Its Impact on Adverse Pregnancy Outcomes. China Pract Med, 16(14): 125–128.