Objective: To explore the application of mindfulness-based stress reduction (MBSR) therapy in patients with postpartum mood disorders and its impact on quality of life. Methods: A total of 61 patients with postpartum mood disorders admitted to our hospital from June 2023 to June 2025 were selected and divided into a control group (n = 30, receiving routine intervention) and an observation group (n = 31, receiving additional MBSR therapy) using the red-blue ball method. Changes in mood disorders, serum serotonin, dopamine, norepinephrine, and quality of life were compared between the two groups. Results: After intervention, the anxiety and depression scores in the observation group were significantly lower than those in the control group (all P < 0.05). After intervention, the serum levels of serotonin, dopamine, and norepinephrine in the observation group were significantly higher than those in the control group (all P < 0.05). After intervention, the quality of life score in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion: The application of MBSR therapy in patients with postpartum mood disorders can significantly reduce anxiety and depression, improve serum serotonin, dopamine, and norepinephrine levels, and enhance quality of life, which is worthy of recognition.
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