Keywords
Screening
TCT
Detection of HPV-DNA typing
Submitted : 2025-06-11
Accepted : 2025-06-26
Published : 2025-07-11
Abstract
Objective: To explore the importance of combined diagnosis (TCT+HPV-DNA) in cervical cancer screening for diagnosis and treatment. Methods: From March 2024 to December 2024, 35 cases were diagnosed as positive by the gold standard (colposcopy biopsy), and then screened by TCT and HPV-DNA typing respectively, and the different results were analyzed. Results: Compared with TCT+HPV-DNA typing, the coincidence rate, specificity and sensitivity of TCT and HPV-DNA typing were significantly lower (P<0.05). Conclusion: Combined diagnosis (i.e. TCT+HPV-DNA typing test) in cervical cancer screening can ensure the accuracy of the results and prompt patients to obtain targeted treatment plans at an early stage.
References
Meng H, Chen Y, Zhou J, et al., 2022, Diagnostic Value of TCT Combined With HPV-DNA Genotyping in Cervical Precancerous Lesions and Cervical Cancer, and the Clinical Significance of P16 and Ki67 Detection. Journal of Clinical and Experimental Medicine, 21(6): 649–652.
Wang S, Wang Y, Wang M, et al., 2023, Application Value of TCT and HPV-DNA in Cervical Cancer Screening Among Postmenopausal Women. Hebei Medical Journal, 45(6): 861–864.
Li J, Dong Y, Wang Y, et al., 2023, Comparison of the Effects of PAX1 Gene DNA Methylation Detection and HPV-DNA Genotyping in Cervical Precancerous Lesions. Medical Journal of the Chinese People’s Armed Police Forces, 34(1): 18–21.
Zhang L, Yang S, Huang W, et al., 2024, Value Analysis of HPV-DNA Genotyping Combined With E6/E7 mRNA Detection in Cervical Cancer Screening. Smart Healthcare, 10(13): 101–104.
Huang Y, 2024, Application Value of HR-HPV DNA Combined With TCT in Screening Cervical Precancerous Lesions. Clinical Medical Research and Practice, 9(2): 97–100.
Chen J, Jin C, Zhou H, et al., 2024, Detection of HPV Genotyping in Patients With Cervical Lesions and Its Clinical Significance. Chinese and Foreign Medical Research, 22(7): 70–74.
Wang J, Chai X, Wang W, 2024, Clinical Effect of High-Risk HPV Detection and TCT Examination in Cervical Cancer Screening and Diagnosis. Aerospace Medicine, 35(7): 795–797.
Liu Q, 2024, Application of HPV Genotyping Combined With TCT in Early Cervical Cancer Screening. Marriage, Childbearing & Health, 2024(14): 22–24.
Xiong X, 2024, Clinical Value of HPV-DNA Genotyping Combined With TCT in Cervical Cancer Screening. Modern Diagnosis & Treatment, 35(7): 1048–1049.