Keywords
Triphenyl phosphate
Pregnancy exposure
Gestational diabetes mellitus
Submitted : 2025-06-08
Accepted : 2025-06-23
Published : 2025-07-08
Abstract
Introduction: Triphenyl phosphates, or TPhPs, are a family of newly discovered pollutants that contaminate the environment, endanger ecological safety, and cause health problems for people when they linger in the surrounding environment for extended periods of time. Methods: This study reviewed the state of the research on the environmental distribution of TPhP, the amount of TPhP exposure during pregnancy, the relationship between TPhP exposure and gestational diabetes mellitus, the possible mechanism by which TPhP exposure during pregnancy causes gestational diabetes mellitus, and the risk of gestational diabetes mellitus in the offspring as a result of TPhP exposure during pregnancy. Results: During pregnancy, if pregnant women come into contact with TPhP, which is widely used in various industrial products, it is highly likely to disrupt the body’s metabolic balance, have a significant impact on the induction of gestational diabetes mellitus, and increase the health risks for both the mother and the baby. Discussion: These findings provide critical insights for risk assessment and prevention strategies targeting gestational TPhP exposure. Significance: What is already known about this subject? TPhP is a pollutant that is harmful to people’s health. When pregnant women are exposed to TPhP for a long time, their chances of developing gestational diabetes increase. What does this study add? This paper systematically summarizes the effects and mechanisms of TPhP on pregnant women, and provides theoretical support and factual basis for the research on TPhP and gestational diabetes.
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