Keywords
Therapy
Anticoagulation
Thrombosis
Coagulation monitoring
Heparin
Submitted : 2025-06-08
Accepted : 2025-06-23
Published : 2025-07-08
Abstract
Preeclampsia (PE) is a multisystem pregnancy disorder. Several pathological processes, such as vascular endothelial dysfunction, an imbalance between coagulation and anticoagulation, and changes in trophoblast characteristics, are involved in the development of PE. The article discusses the pathogenesis of PE. In the third trimester, a protective hypercoagulable state typically develops in normal pregnancies. However, in PE, this state is exacerbated, resulting in a thrombotic phenotype characterized by a systemic inflammatory response and activation of the clotting cascade. This article examines the potential mechanisms involved. The present treatment emphasizes the timely delivery of the fetus. The investigation of anticoagulant therapies is still ongoing, mainly focusing on aspirin and the use of low-molecular-weight heparin for drug-induced thrombosis prevention. In this review, we will summarize the recent findings of reported and ongoing anticoagulation therapy in the treatment of PE. This anticoagulant treatment strategy is essential for the improvement and prevention of PE.
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