Objective:Â To observe the clinical efficacy of octreotide andÂ thrombin in the treatment of patients with liver cirrhosis, and toÂ explore the mechanism of octreotide and thrombin. Methods:Â 53 patients with cirrhosis were randomly divided into controlÂ group and observation group from January 2014 to JanuaryÂ 2016. The control group of 26 patients, given octreotide treatment. Observation group of 27 cases, given octreotide andÂ thrombin combination therapy. Comparison of two groups ofÂ patients with clinical efficacy and changes in liver function before and after treatment.Â Results: The effective rate (88.89%)Â in the observation group was significantly higher than that inÂ the control group (65.38%), the difference was statistically significant (p < 0.05). Before treatment, the difference of liverÂ function between the two groups was not statistically significant (p > 0.05). After treatment, the liver function indexes ofÂ the two groups were improved, and the observation group wasÂ superior to the control group, the difference was statisticallyÂ significant (p < 0.05).