Objective: To evaluate the safety and efficacy of ultra-percutaneous nephrotic access combined with 30 cm FURS in the treatment of multiple nephrolithiasis in children. Methods: From October 2016 to March 2018, 30 children with multiple nephrolithiasis (age range 2 to 10 years old) were admitted to our hospital with ultra-perc combined with 30 cm FURS holmium laser lithotripsy The patients' operation time, hospitalization time, stone freel rate, blood loss before and after surgery, C-reactive protein, leukocyte, platelet and other stress factors, creatinine, urea nitrogen and other indicators of renal function, Renal scintigraphy was used to evaluation the injury of renal parenchymal. Results: The use of ultra-perc combined with 30 cm FURS, the first lithotomy was 93%, 2 patients were staged surgery, staging clearance rate of 100% (30/30) operation time 20 to 50 minutes, the average 35 minutes, average postoperative hospital stay 2 days, postoperative hemoglobin decreased no significant change. No transfusion in children, before and after surgery creatinine, urea nitrogen and CRP leukocytes, platelet and other grades were no significant differences, in Renal scintigraphy renal parenchymal injury was not obvious. Follow-up from 6 months to 1 year, no long-term complications in all children. Conclusion: Ultra-percutaneous nephrotic access combined with 30 cm FURS in the treatment of multiple nephrolithiasis in children is safe and effective.