Objective: To observe the therapeutic effect of salvia miltiorrhiza phenylephrine combined with puerarin sodium on diabetic peripheral neuropathy (DPN) and the effect of serumÂ insulin-like growth factor 1 (IGF-1), free fatty acid (FFA) andÂ human myelin Protein (MBP). Methods: A total of 116 patients with diabetic peripheral neuropathy were randomly divided into observation group (58 cases) and control group (58Â cases). The control group was treated with sodium prostaglandin sodium. The observation group was treated with Danshephenolic acid Treatment, treatment for 8 weeks. The changesÂ of total symptom score system (TSS), vibration sensory threshold (VPT), ankle brachial index (ABI) and peripheral nerveÂ conduction velocity (NCV), serum IGF-1, FFA and MBP wereÂ observed before and after treatment.Â Results: The levels ofÂ numbness, tingling, burning, paresthesia and total score wereÂ significantly decreased in both groups after treatment, VPT,Â ABI and NCV wereÂ improved (P < 0.05), and the above indexes (P < 0.05). The levels of serum IGF-1 were increasedÂ and the levels of FFA and MBP were lower in the two groups.Â The improvement of the above indexes was better than that ofÂ the control group (P < 0.05). Conclusion: Salvia miltiorrhizaÂ polyphenate combined with puerarin sodium can significantlyÂ improve the vibration sensory threshold and ankle-brachial index, enhance the nerve conduction velocity and relieve clinicalÂ symptoms in patients with diabetic peripheral neuropathy. TheÂ mechanism may be related to the regulation of serum IGF-1,FFA, The level of MBP is relevant.