Objective: To explore the effect of the nursing intervention inÂ patients with functional gastrointestinal diseases. Methods: 79functional gastrointestinal patients were selected from February 2015 to February 2016, and these patients were randomlyÂ divided into observation group and control group. 35 patientsÂ in each group. In the routine care of the medical department,the observation group has strengthened the comprehensiveÂ nursing care for the patientâ€™s psychological, the living diet, theÂ living environment, and the patientâ€™s health education on theÂ basis of the conventional nursing care. SCL-90 score was usedÂ to analyze the patientâ€™s care and observe the health of the twoÂ groups after nursing care. Results:Â The scores of SAS and SDSÂ were compared between the two groups after the interventionÂ of the two groups. The scores of the two groups were decreasedÂ before the nursing intervention, the difference was statisticallyÂ significant, but the trend of the observation group was moreÂ obvious. Compared with the control group, compared with before treatment there is a certain difference, the difference wasÂ statistically significant. Conclusion:Â In the comprehensiveÂ care of gastrointestinal patients, it can obviously improve theÂ anxiety and depression of functional patients and improve theÂ quality of life of patients.