Objective: To investigate the clinical effect of single-row fixation and non-conjunction compression in the treatment of post small and medium rotator cuff injuries under arthroscopy. Methods: Forty-five patients admitted to our department from June 2017 to May 2019 were enrolled in the study. 32 patients in the single-row fixed-group and 13 patients in the non-conjunctival group were randomly assigned. The VAS, ASES, and UCLA scores of the two groups were compared before surgery, one month, three months, and six months after surgery. Results: The VAS, ASES, and UCLA scores were significantly higher in those two groups other than the preoperative group. The scores of the two groups were gradually improved from one month, three months, and six months respectively after surgery. At one month, the scores of those two groups were statistically significant (P<0.05), but there was no significant difference between the two groups at three months and six months (P>0.05). Conclusion: Under arthroscopy, the single-row fixation technique and the non-conjunction compression method were used to treat post small and medium rotator cuff injuries. The effect is very significant. In particular, the no-knot sputum method has a significant improvement in restoring postoperative pain, joint activity and joint strength.